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Summary
Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) pipeline Target constitutes close to 19 molecules. Out of which approximately 17 molecules are developed by companies and remaining by the universities/institutes. The latest report Poly [ADP Ribose] Polymerase 2 - Pipeline Review, H1 2020, outlays comprehensive information on the Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.
Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Poly [ADP-ribose] polymerase 2 is an enzyme encoded by the PARP2 gene. It is involved in the base excision repair (BER) pathway, by catalyzing the poly (ADP-ribosylation) of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in signaling pathway leading to the reparation of DNA strand breaks.
The molecules developed by companies in Pre-Registration, Phase III, Phase II, Phase I and Preclinical stages are 2, 5, 3, 5 and 2 respectively. Similarly, the universities portfolio in Preclinical stages comprises 2 molecules, respectively. Report covers products from therapy areas Oncology which include indications Ovarian Cancer, Endometrial Cancer, Fallopian Tube Cancer, Solid Tumor, Triple-Negative Breast Cancer (TNBC), Breast Cancer, Peritoneal Cancer, Cervical Cancer, Epithelial Ovarian Cancer, Metastatic Breast Cancer, Prostate Cancer, Small-Cell Lung Cancer, Gastric Cancer, Metastatic Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer, Non-Small Cell Lung Cancer, Adenocarcinoma Of The Gastroesophageal Junction, Bile Duct Cancer (Cholangiocarcinoma), Malignant Mesothelioma, Metastatic Adenocarcinoma of The Pancreas, Metastatic Pancreatic Cancer, Pancreatic Cancer, Transitional Cell Cancer (Urothelial Cell Cancer), Diffuse Large B-Cell Lymphoma, Glioblastoma Multiforme (GBM), Bladder Cancer, Colorectal Cancer, Esophageal Cancer, Glioma, Head And Neck Cancer Squamous Cell Carcinoma, Leiomyosarcoma, Lung Cancer, Mantle Cell Lymphoma, Melanoma, Metastatic Biliary Tract Cancer, Metastatic Colorectal Cancer, Metastatic Renal Cell Carcinoma, Muscle Invasive Bladder Cancer (MIBC), Neuroblastoma, Non-Hodgkin Lymphoma, Oropharyngeal Cancer, Peritoneal Tumor, Renal Cell Carcinoma, Squamous Non-Small Cell Lung Cancer, Transitional Cell Carcinoma (Urothelial Cell Carcinoma), Uterine Cancer, Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Acute Promyelocytic Leukemia, Anaplastic Astrocytoma, B-Cell Chronic Lymphocytic Leukemia, Biliary Tumor, Bone Sarcoma, Brenner Tumor, Chronic Lymphocytic Leukemia (CLL), Chronic Myelocytic Leukemia (CML, Chronic Myeloid Leukemia), Clear Cell Squamous Cell Carcinoma, Essential Thrombocythemia, Ewing Sarcoma, Follicular Lymphoma, Germ Cell Tumors, Germinomatous (Seminomatous) Germ Cell Tumors, Head And Neck Cancer, High-Grade Glioma, Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer, Hormone-Sensitive Prostate Cancer, Intestinal Cancer, Kidney Cancer (Renal Cell Cancer), Laryngeal Cancer, Liposarcoma, Low-Grade Glioma, Marginal Zone B-cell Lymphoma, Metastatic Melanoma, Metastatic Ovarian Cancer, Metastatic Transitional (Urothelial) Tract Cancer, Myelofibrosis, Myeloproliferative Disorders, Natural Killer Cell Lymphomas, Neuroendocrine Tumors, Nongerminomatous (Nonseminomatous) Germ Cell Tumors, Pancreatic Ductal Adenocarcinoma, Peripheral Nerve Sheath Tumor (Neurofibrosarcoma), Polycythemia Vera, Rectal Cancer, Recurrent Glioblastoma Multiforme (GBM), Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Sarcomas, Soft Tissue Sarcoma, T-Cell Lymphomas, Testicular Cancer, Ureter Cancer, Urethral Cancer and Uveal Melanoma.
Note: Certain content/sections in the pipeline guide may be removed or altered based on the availability and relevance of data.
Scope
- The report provides a snapshot of the global therapeutic landscape for Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30)
- The report reviews Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) targeted therapeutics and enlists all their major and minor projects
- The report assesses Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) targeted therapeutics
Reasons to buy
- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope
Table of Contents
- Introduction
- Report Coverage
- Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Overview
- Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Therapeutics Development
- Products under Development by Stage of Development
- Products under Development by Therapy Area
- Products under Development by Indication
- Products under Development by Companies
- Products under Development by Universities/Institutes
- Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Therapeutics Assessment
- Assessment by Mechanism of Action
- Assessment by Route of Administration
- Assessment by Molecule Type
- Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Companies Involved in Therapeutics Development
- AbbVie Inc
- AstraZeneca Plc
- BeiGene Ltd
- Clovis Oncology Inc
- Convalife
- GlaxoSmithKline Plc
- Hubei Bio-Pharmaceutical Industrial Technological Institute Inc
- Ildong Pharmaceutical Co Ltd
- Jeil Pharmaceutical Co Ltd
- Jiangsu Hengrui Medicine Co Ltd
- Oncology Venture U.S. Inc
- Shanghai Acebright Pharmaceuticals Group Co Ltd
- Shanghai De Novo Pharmatech Co Ltd
- Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Drug Profiles
- 2X-121 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- ABT-767 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- AZ-0108 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- cediranib maleate + olaparib - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- ceralasertib + olaparib - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- CVL-218 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- HWH-340 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- IDX-1197 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- JPI-547 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- niraparib - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- olaparib - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- pamiparib - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- rucaparib camsylate - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- SC-10914 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- SHR-3162 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Small Molecules to Target NO and PARP 1, 2, 3 for Oncology - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- SOMCL-9112 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- veliparib ER - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- YHP-743 - Drug Profile
- Product Description
- Mechanism Of Action
- R&D Progress
- Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Dormant Products
- Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Discontinued Products
- Poly [ADP Ribose] Polymerase 2 (ADP Ribosyltransferase Diphtheria Toxin Like 2 or NAD(+) ADP Ribosyltransferase 2 or Poly[ADP Ribose] Synthase 2 or PARP2 or EC 2.4.2.30) - Product Development Milestones
- Featured News & Press Releases
- Appendix
List of Tables
- Number of Products under Development by Stage of Development, H1 2020
- Number of Products under Development by Therapy Areas, H1 2020
- Number of Products under Development by Indications, H1 2020
- Number of Products under Development by Indications, H1 2020 (Contd..1), H1 2020
- Number of Products under Development by Indications, H1 2020 (Contd..2), H1 2020
- Number of Products under Development by Indications, H1 2020 (Contd..3), H1 2020
- Number of Products under Development by Indications, H1 2020 (Contd..4), H1 2020
- Number of Products under Development by Companies, H1 2020
- Products under Development by Companies, H1 2020
- Products under Development by Companies, H1 2020 (Contd..1), H1 2020
- Products under Development by Companies, H1 2020 (Contd..2), H1 2020
- Products under Development by Companies, H1 2020 (Contd..3), H1 2020
- Products under Development by Companies, H1 2020 (Contd..4), H1 2020
- Products under Development by Companies, H1 2020 (Contd..5), H1 2020
- Products under Development by Companies, H1 2020 (Contd..6), H1 2020
- Products under Development by Companies, H1 2020 (Contd..7), H1 2020
- Products under Development by Companies, H1 2020 (Contd..8), H1 2020
- Products under Development by Companies, H1 2020 (Contd..9), H1 2020
- Products under Development by Companies, H1 2020 (Contd..10), H1 2020
- Products under Development by Companies, H1 2020 (Contd..11), H1 2020
- Products under Development by Companies, H1 2020 (Contd..12), H1 2020
- Products under Development by Companies, H1 2020 (Contd..13), H1 2020
- Number of Products under Investigation by Universities/Institutes, H1 2020
- Products under Investigation by Universities/Institutes, H1 2020
- Number of Products by Stage and Mechanism of Actions, H1 2020
- Number of Products by Stage and Route of Administration, H1 2020
- Number of Products by Stage and Molecule Type, H1 2020
- Pipeline by AbbVie Inc, H1 2020
- Pipeline by AstraZeneca Plc, H1 2020
- Pipeline by BeiGene Ltd, H1 2020
- Pipeline by Clovis Oncology Inc, H1 2020
- Pipeline by Convalife, H1 2020
- Pipeline by GlaxoSmithKline Plc, H1 2020
- Pipeline by Hubei Bio-Pharmaceutical Industrial Technological Institute Inc, H1 2020
- Pipeline by Ildong Pharmaceutical Co Ltd, H1 2020
- Pipeline by Jeil Pharmaceutical Co Ltd, H1 2020
- Pipeline by Jiangsu Hengrui Medicine Co Ltd, H1 2020
- Pipeline by Oncology Venture U.S. Inc, H1 2020
- Pipeline by Shanghai Acebright Pharmaceuticals Group Co Ltd, H1 2020
- Pipeline by Shanghai De Novo Pharmatech Co Ltd, H1 2020
- Dormant Products, H1 2020
- Dormant Products, H1 2020 (Contd..1), H1 2020
- Discontinued Products, H1 2020
List of Figures
- Number of Products under Development by Stage of Development, H1 2020
- Number of Products under Development by Top 10 Indications, H1 2020
- Number of Products by Stage and Mechanism of Actions, H1 2020
- Number of Products by Stage and Route of Administration, H1 2020
- Number of Products by Stage and Molecule Type, H1 2020
Companies Mentioned (Partial List)
A selection of companies mentioned in this report includes, but is not limited to:
- AbbVie Inc
- AstraZeneca Plc
- BeiGene Ltd
- Clovis Oncology Inc
- Convalife
- GlaxoSmithKline Plc
- Hubei Bio-Pharmaceutical Industrial Technological Institute Inc
- Ildong Pharmaceutical Co Ltd
- Jeil Pharmaceutical Co Ltd
- Jiangsu Hengrui Medicine Co Ltd
- Oncology Venture U.S. Inc
- Shanghai Acebright Pharmaceuticals Group Co Ltd
- Shanghai De Novo Pharmatech Co Ltd
